A new role of p53 in regulating lipid metabolism
نویسندگان
چکیده
منابع مشابه
A new role of p53 in regulating lipid metabolism.
Dear Editor, The p53 tumor suppressor maintains the normal cell growth and genomic stability by launching cell cycle arrest, DNA repair, or apoptosis in response to DNA damage or other forms of cellular stress. Recent studies also suggest that p53 is capable of much broader cellular functions, including the regulation of energy metabolism and autophagy. However, the role of p53 in regulating li...
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15 صفحه اولp53, a novel regulator of lipid metabolism pathways
BACKGROUND & AIMS In this study we aimed at characterizing the regulation of hepatic metabolic pathways by the p53 transcription factor. METHODS Analysis of gene expression following alteration of p53 status in several human- and mouse-derived cells using microarray analysis, quantitative real-time PCR, chromatin immunoprecipitation, and reporter gene assays. A functional assay was performed ...
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ژورنال
عنوان ژورنال: Journal of Molecular Cell Biology
سال: 2012
ISSN: 1759-4685,1674-2788
DOI: 10.1093/jmcb/mjs064